A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults
Metadatos
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Martínez Téllez, Borja Manuel; Sánchez Delgado, Guillermo; García Rivero, Yolanda; Alcántara Alcántara, Juan Manuel; Martínez Ávila, Wendy D.; Muñoz Hernández, María Victoria; Olza, Josune; R. Boon, Mariëtte; C. N. Rensen, Patrick; Llamas Elvira, José Manuel; R. Ruiz, JonatanEditorial
Frontiers Media
Materia
cooling vest PET/CT scan glucose uptake
Fecha
2017-11-02Referencia bibliográfica
Martínez Téllez, B. et. al. Front. Physiol. 8:863. [https://doi.org/10.3389/fphys.2017.00863]
Patrocinador
Spanish Ministry of Economy and Competitiveness, Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393), Fondos Estructurales de la Unión Europea (FEDER), by the Spanish Ministry of Education (FPU 13/04365 and 15/04059); Fundación Iberoamericana de Nutrición (FINUT); Redes temáticas de investigación cooperativa RETIC (Red SAMID RD16/0022); AstraZeneca HealthCare Foundation and by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES); Dutch Diabetes Foundation (grant 2015.81.1808); Established Investigator of the Netherlands Heart Foundation (grant 2009T038)Resumen
Brown adipose tissue (BAT) activity is induced when humans are exposed to cold.
Therefore, cold exposure prior to the 18F-FDG-PET/CT scan is used as a tool to quantify
BAT. Several cooling protocols, including fixed and personalized ones are currently in
use. The aim of the present study was to determine the effect of a new personalized
cooling protocol where the shivering threshold was measured on a separate day, on
BAT volume and activity in young adults. A total of 47 adults (n = 28 women) aged
22 ± 2 years participated in the study. We determined participants’ shivering threshold
(visually and self-reported) using a water perfused cooling vest in an air-conditioned cold
room. 48–72 h later, participants wore the cooling vest set at ∼4◦C above the shivering
threshold for 60min prior to injection of 18F-FDG and ∼5◦C above the shivering threshold
for ∼60min after injection, until PET/CT scan. We quantified BAT following BARCIST 1.0
recommendations. We identified 40 participants (85%, n = 25 women) as PET+ and
7 (n = 3 women) as PET–. The PET+ group presented significantly higher BAT volume
and activity than PET– group (all P < 0.05). PET+ women had higher BAT mean activity
than PET+ men (SUVmean: 5.0 ± 1.6 vs. 3.6 ± 0.9 g/ml respectively, P = 0.003), and
there were no significant sex differences in BAT volume (P = 0.161). A total of 9 out
of 47 participants did not shiver during the shivering threshold test. Our findings are
similar to previous cold-stimulated human BAT studies; therefore, we conclude that our
personalized cooling protocol is able to activate BAT in young adults.