@misc{10481/97349,
year = {2017},
month = {11},
url = {https://hdl.handle.net/10481/97349},
abstract = {Brown adipose tissue (BAT) activity is induced when humans are exposed to cold.
Therefore, cold exposure prior to the 18F-FDG-PET/CT scan is used as a tool to quantify
BAT. Several cooling protocols, including fixed and personalized ones are currently in
use. The aim of the present study was to determine the effect of a new personalized
cooling protocol where the shivering threshold was measured on a separate day, on
BAT volume and activity in young adults. A total of 47 adults (n = 28 women) aged
22 ± 2 years participated in the study. We determined participants’ shivering threshold
(visually and self-reported) using a water perfused cooling vest in an air-conditioned cold
room. 48–72 h later, participants wore the cooling vest set at ∼4◦C above the shivering
threshold for 60min prior to injection of 18F-FDG and ∼5◦C above the shivering threshold
for ∼60min after injection, until PET/CT scan. We quantified BAT following BARCIST 1.0
recommendations. We identified 40 participants (85%, n = 25 women) as PET+ and
7 (n = 3 women) as PET–. The PET+ group presented significantly higher BAT volume
and activity than PET– group (all P < 0.05). PET+ women had higher BAT mean activity
than PET+ men (SUVmean: 5.0 ± 1.6 vs. 3.6 ± 0.9 g/ml respectively, P = 0.003), and
there were no significant sex differences in BAT volume (P = 0.161). A total of 9 out
of 47 participants did not shiver during the shivering threshold test. Our findings are
similar to previous cold-stimulated human BAT studies; therefore, we conclude that our
personalized cooling protocol is able to activate BAT in young adults.},
organization = {Spanish Ministry of Economy
and Competitiveness, Fondo de Investigación Sanitaria del
Instituto de Salud Carlos III (PI13/01393), Fondos Estructurales
de la Unión Europea (FEDER), by the Spanish Ministry of
Education (FPU 13/04365 and 15/04059)},
organization = {Fundación
Iberoamericana de Nutrición (FINUT)},
organization = {Redes temáticas
de investigación cooperativa RETIC (Red SAMID RD16/0022)},
organization = {AstraZeneca HealthCare Foundation and by the University of
Granada, Plan Propio de Investigación 2016, Excellence actions:
Units of Excellence; Unit of Excellence on Exercise and Health
(UCEES)},
organization = {Dutch Diabetes Foundation
(grant 2015.81.1808)},
organization = {Established Investigator of the
Netherlands Heart Foundation (grant 2009T038)},
publisher = {Frontiers Media},
keywords = {cooling vest},
keywords = {PET/CT scan},
keywords = {glucose uptake},
title = {A New Personalized Cooling Protocol to Activate Brown Adipose Tissue in Young Adults},
doi = {10.3389/fphys.2017.00863},
author = {Martínez Téllez, Borja Manuel and Sánchez Delgado, Guillermo and García Rivero, Yolanda and Alcántara Alcántara, Juan Manuel and Martínez Ávila, Wendy D. and Muñoz Hernández, María Victoria and Olza, Josune and R. Boon, Mariëtte and C. N. Rensen, Patrick and Llamas Elvira, José Manuel and R. Ruiz, Jonatan},
}