A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model
Metadatos
Mostrar el registro completo del ítemAutor
Guzmán Carrasco, Ana Isabel; Kapravelou, Garyfallia; López-Jurado Romero De La Cruz, María; Bermúdez, Francisco; Andrés León, Eduardo; Terrón Camero, Laura Carmen; Prados Salazar, José Carlos; Melguizo Alonso, Consolación; Porres Foulquie, Jesús María; Martínez Martínez, RosarioMateria
Obesity Oxidative stress Natural extracts Antioxidants Physical exercise
Fecha
2024-02-23Referencia bibliográfica
Guzmán-Carrasco, A.; Kapravelou, G.; López-Jurado, M.; Bermúdez, F.; Andrés-León, E.; Terrón-Camero, L.C.; Prados, J.; Melguizo, C.; Porres, J.M.; Martínez, R. A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model. Antioxidants 2024, 13, 274. https://doi.org/10.3390/antiox 13030274
Patrocinador
Consejería de Universidad, Investigación e Innovación. Grant ID: P18-TP-1420; Ministerio de Ciencia e Innovación. Grant ID: PID2022-141291OB-I00, RTC2019-006870-1, TED2021-131241A-I00Resumen
The prevalence of obesity increases alarmingly every year mostly due to external factors
such as high-fat and high-refined sugar intake associated with a sedentary lifestyle. It triggers
metabolic disorders such as insulin resistance, hyperlipemia, non-alcoholic fatty liver disease, chronic
inflammation, oxidative stress, and gut microbiota dysbiosis. The aim of this study was to evaluate the
beneficial effects of a combined intervention with caloric restriction, nutraceutical intake, and a mixed
training protocol on oxidative stress, inflammation, and gut dysbiosis derived from the development
of obesity in a C57BL6/J mouse experimental model of diet-induced obesity (4.6 Kcal/g diet, 45% Kcal
as fat, and 20% fructose in the drinking fluid). The nutraceutical was formulated with ethanolic
extracts of Argania spinosa pulp (10%) and Camelina sativa seeds (10%) and with protein hydrolysates
from Psoralea corylifolia seeds (40%) and Spirodela polyrhiza whole plants (40%). The combination of
nutraceutical and exercise decreased the animals’ body weights and inflammatory markers (TNFα,
IL-6, and resistin) in plasma, while increasing gene expression of cat, sod2, gsta2, and nqo1 in the liver.
Obese animals showed lower β-diversity of microbiota and a higher Firmicutes/Bacteroidetes ratio
vs. normocaloric controls that were reversed by all interventions implemented. Dietary inclusion of a
nutraceutical with high antioxidant potential combined with an exercise protocol can be beneficial for
bodyweight control and improvement of metabolic status in patients undergoing obesity treatment.