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A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model
dc.contributor.author | Guzmán Carrasco, Ana Isabel | |
dc.contributor.author | Kapravelou, Garyfallia | |
dc.contributor.author | López-Jurado Romero De La Cruz, María | |
dc.contributor.author | Bermúdez, Francisco | |
dc.contributor.author | Andrés León, Eduardo | |
dc.contributor.author | Terrón Camero, Laura Carmen | |
dc.contributor.author | Prados Salazar, José Carlos | |
dc.contributor.author | Melguizo Alonso, Consolación | |
dc.contributor.author | Porres Foulquie, Jesús María | |
dc.contributor.author | Martínez Martínez, Rosario | |
dc.date.accessioned | 2024-05-27T10:38:32Z | |
dc.date.available | 2024-05-27T10:38:32Z | |
dc.date.issued | 2024-02-23 | |
dc.identifier.citation | Guzmán-Carrasco, A.; Kapravelou, G.; López-Jurado, M.; Bermúdez, F.; Andrés-León, E.; Terrón-Camero, L.C.; Prados, J.; Melguizo, C.; Porres, J.M.; Martínez, R. A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model. Antioxidants 2024, 13, 274. https://doi.org/10.3390/antiox 13030274 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/92105 | |
dc.description.abstract | The prevalence of obesity increases alarmingly every year mostly due to external factors such as high-fat and high-refined sugar intake associated with a sedentary lifestyle. It triggers metabolic disorders such as insulin resistance, hyperlipemia, non-alcoholic fatty liver disease, chronic inflammation, oxidative stress, and gut microbiota dysbiosis. The aim of this study was to evaluate the beneficial effects of a combined intervention with caloric restriction, nutraceutical intake, and a mixed training protocol on oxidative stress, inflammation, and gut dysbiosis derived from the development of obesity in a C57BL6/J mouse experimental model of diet-induced obesity (4.6 Kcal/g diet, 45% Kcal as fat, and 20% fructose in the drinking fluid). The nutraceutical was formulated with ethanolic extracts of Argania spinosa pulp (10%) and Camelina sativa seeds (10%) and with protein hydrolysates from Psoralea corylifolia seeds (40%) and Spirodela polyrhiza whole plants (40%). The combination of nutraceutical and exercise decreased the animals’ body weights and inflammatory markers (TNFα, IL-6, and resistin) in plasma, while increasing gene expression of cat, sod2, gsta2, and nqo1 in the liver. Obese animals showed lower β-diversity of microbiota and a higher Firmicutes/Bacteroidetes ratio vs. normocaloric controls that were reversed by all interventions implemented. Dietary inclusion of a nutraceutical with high antioxidant potential combined with an exercise protocol can be beneficial for bodyweight control and improvement of metabolic status in patients undergoing obesity treatment. | es_ES |
dc.description.sponsorship | Consejería de Universidad, Investigación e Innovación. Grant ID: P18-TP-1420 | es_ES |
dc.description.sponsorship | Ministerio de Ciencia e Innovación. Grant ID: PID2022-141291OB-I00, RTC2019-006870-1, TED2021-131241A-I00 | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Obesity | es_ES |
dc.subject | Oxidative stress | es_ES |
dc.subject | Natural extracts | es_ES |
dc.subject | Antioxidants | es_ES |
dc.subject | Physical exercise | es_ES |
dc.title | A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/antiox13030274 | |
dc.type.hasVersion | VoR | es_ES |