@misc{10481/92105,
year = {2024},
month = {2},
url = {https://hdl.handle.net/10481/92105},
abstract = {The prevalence of obesity increases alarmingly every year mostly due to external factors
such as high-fat and high-refined sugar intake associated with a sedentary lifestyle. It triggers
metabolic disorders such as insulin resistance, hyperlipemia, non-alcoholic fatty liver disease, chronic
inflammation, oxidative stress, and gut microbiota dysbiosis. The aim of this study was to evaluate the
beneficial effects of a combined intervention with caloric restriction, nutraceutical intake, and a mixed
training protocol on oxidative stress, inflammation, and gut dysbiosis derived from the development
of obesity in a C57BL6/J mouse experimental model of diet-induced obesity (4.6 Kcal/g diet, 45% Kcal
as fat, and 20% fructose in the drinking fluid). The nutraceutical was formulated with ethanolic
extracts of Argania spinosa pulp (10%) and Camelina sativa seeds (10%) and with protein hydrolysates
from Psoralea corylifolia seeds (40%) and Spirodela polyrhiza whole plants (40%). The combination of
nutraceutical and exercise decreased the animals’ body weights and inflammatory markers (TNFα,
IL-6, and resistin) in plasma, while increasing gene expression of cat, sod2, gsta2, and nqo1 in the liver.
Obese animals showed lower β-diversity of microbiota and a higher Firmicutes/Bacteroidetes ratio
vs. normocaloric controls that were reversed by all interventions implemented. Dietary inclusion of a
nutraceutical with high antioxidant potential combined with an exercise protocol can be beneficial for
bodyweight control and improvement of metabolic status in patients undergoing obesity treatment.},
organization = {Consejería de Universidad, Investigación e Innovación. Grant ID: P18-TP-1420},
organization = {Ministerio de Ciencia e Innovación. Grant ID: PID2022-141291OB-I00, RTC2019-006870-1, TED2021-131241A-I00},
keywords = {Obesity},
keywords = {Oxidative stress},
keywords = {Natural extracts},
keywords = {Antioxidants},
keywords = {Physical exercise},
title = {A Novel Plant-Based Nutraceutical Combined with Exercise Can Revert Oxidative Status in Plasma and Liver in a Diet-Induced-Obesity Animal Model},
doi = {10.3390/antiox13030274},
author = {Guzmán Carrasco, Ana Isabel and Kapravelou, Garyfallia and López-Jurado Romero De La Cruz, María and Bermúdez, Francisco and Andrés León, Eduardo and Terrón Camero, Laura Carmen and Prados Salazar, José Carlos and Melguizo Alonso, Consolación and Porres Foulquie, Jesús María and Martínez Martínez, Rosario},
}