Drug

Sánchez Martín, Rosario María

doi:doi.org/10.1021/acs.bioconjchem.8b00481

Articulo Principal (1.742Mb)

Identificadores

URI: https://hdl.handle.net/10481/88536

DOI: doi.org/10.1021/acs.bioconjchem.8b00481

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Editorial

ACS Publications

Fecha

2018-08-18

Referencia bibliográfica

Valero T, Delgado-González A, Unciti-Broceta J D, Cano-Cortés V, Pérez-López A M , Unciti-Broceta A, Sánchez Martín R M. Bioconjugate Chem. 2018, 29, 9, 3154–3160, https://doi.org/10.1021/acs.bioconjchem.8b00481

Resumen

This paper introduces a novel method for identifying molecular targets of drugs by conjugating azide-labeled drugs with alkyne-tagged cell-penetrating fluorescent nanoparticles using click chemistry. A modified Baeyer test for alkynes monitors the Cu(I)-catalyzed azide–alkyne cycloaddition reaction, ensuring drug presence on solid support. Dasatinib-conjugated nanoparticles effectively inhibit the SRC protein target in vitro and demonstrate intracellular colocalization.

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CTS987 - Artículos

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Drug "Clicking" on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics