@misc{10481/88536,
year = {2018},
month = {8},
url = {https://hdl.handle.net/10481/88536},
abstract = {This paper introduces a novel method for identifying molecular targets of drugs by conjugating azide-labeled drugs with alkyne-tagged cell-penetrating fluorescent nanoparticles using click chemistry. A modified Baeyer test for alkynes monitors the Cu(I)-catalyzed azide–alkyne cycloaddition reaction, ensuring drug presence on solid support. Dasatinib-conjugated nanoparticles effectively inhibit the SRC protein target in vitro and demonstrate intracellular colocalization.},
publisher = {ACS Publications},
title = {Drug "Clicking" on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics},
doi = {doi.org/10.1021/acs.bioconjchem.8b00481},
author = {Sánchez Martín, Rosario María},
}