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Drug "Clicking" on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics
dc.contributor.author | Sánchez Martín, Rosario María | |
dc.date.accessioned | 2024-02-07T10:17:47Z | |
dc.date.available | 2024-02-07T10:17:47Z | |
dc.date.issued | 2018-08-18 | |
dc.identifier.citation | Valero T, Delgado-González A, Unciti-Broceta J D, Cano-Cortés V, Pérez-López A M , Unciti-Broceta A, Sánchez Martín R M. Bioconjugate Chem. 2018, 29, 9, 3154–3160, https://doi.org/10.1021/acs.bioconjchem.8b00481 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/88536 | |
dc.description.abstract | This paper introduces a novel method for identifying molecular targets of drugs by conjugating azide-labeled drugs with alkyne-tagged cell-penetrating fluorescent nanoparticles using click chemistry. A modified Baeyer test for alkynes monitors the Cu(I)-catalyzed azide–alkyne cycloaddition reaction, ensuring drug presence on solid support. Dasatinib-conjugated nanoparticles effectively inhibit the SRC protein target in vitro and demonstrate intracellular colocalization. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACS Publications | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Drug "Clicking" on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | doi.org/10.1021/acs.bioconjchem.8b00481 | |
dc.type.hasVersion | VoR | es_ES |