Cranial and extracranial giant cell arteritis do not exhibit differences in the IL6 -174 G/C gene polymorphism
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Giant cell arteritisLarge-vessel vasculitisIL6 -174 G/C (rs1800795)Polymorphism
Prieto-Peña, D., Remuzgo-Martínez, S., Atienza-Mateo, B. et al. Cranial and extracranial giant cell arteritis do not have different HLA-DRB1 and HLA-B association in Caucasian individuals. Arthritis Res Ther 23, 268 (2021). [https://doi.org/10.1186/s13075-021-02659-9]
SponsorshipInstituto de Salud Carlos III CM20/00006; European Union (EU); Instituto de Salud Carlos III Spanish Government; Marie Curie Actions European Union (EU) RD16/0012/0014 PI17/00409; Research Executive Agency (REA) of the European Union 734899-Olive-Net; Instituto de Salud Carlos III Spanish Government; European Social Fund (ESF) CP16/00033
Since interleukin-6 (IL-6) is a pivotal proinflammatory cytokine implicated in the pathogenesis of giant cell arteritis (GCA), we aimed to determine the potential association of the functional IL6 -174 G/C polymorphism with GCA as well as if the single base change variation at the promoter region in the human IL-6 gene may account for differences in the clinical spectrum of GCA between cranial and extracranial large-vessel vasculitis (LVV)-GCA.