Cranial and extracranial giant cell arteritis do not exhibit differences in the IL6 -174 G/C gene polymorphism Genre, F. Ortego Centeno, Norberto Giant cell arteritis Large-vessel vasculitis IL6 -174 G/C (rs1800795) Polymorphism Since interleukin-6 (IL-6) is a pivotal proinflammatory cytokine implicated in the pathogenesis of giant cell arteritis (GCA), we aimed to determine the potential association of the functional IL6 -174 G/C polymorphism with GCA as well as if the single base change variation at the promoter region in the human IL-6 gene may account for differences in the clinical spectrum of GCA between cranial and extracranial large-vessel vasculitis (LVV)-GCA. 2023-10-03T10:36:16Z 2023-10-03T10:36:16Z 2021-10-26 journal article Prieto-Peña, D., Remuzgo-Martínez, S., Atienza-Mateo, B. et al. Cranial and extracranial giant cell arteritis do not have different HLA-DRB1 and HLA-B association in Caucasian individuals. Arthritis Res Ther 23, 268 (2021). [https://doi.org/10.1186/s13075-021-02659-9] https://hdl.handle.net/10481/84805 10.1186/s13075-021-02659-9 eng info:eu-repo/grantAgreement/EC/EU/RD16/0012/0014 PI17/00409 http://creativecommons.org/licenses/by/4.0/ open access Atribución 4.0 Internacional Springer Nature