Oxime@Zirconium-Metal−Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning
Metadatos
Mostrar el registro completo del ítemAutor
González García, Lydia; Martín Romera, Javier David; Sánchez Sánchez, Purificación; Navarro, Jorge A. R.; Barea Martínez, Elisa María; Rodríguez Maldonado, Carmen; Carmona Fernández, Francisco JesúsEditorial
ACS Publications
Fecha
2023-03-20Referencia bibliográfica
Inorg. Chem. 2023, 62, 5049−5053[https://doi.org/10.1021/acs.inorgchem.3c00121]
Patrocinador
MCIN/AEI PID2020-113608RB-I00; FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P20_00672 P18-RT-612; University of Granada PPJIA2021.20; Marie Sklodowska-Curie Individual Fellowship within the European Union H2020 programme H2020-MSCA-IF-2019-EF-ST-888972-PSustMOF; the European Union H2020; EU FEDER; Garantía Juvenil en I+D+i, PEJ2018-004022-A; Universidad de Granada/CBUA; Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente” (University of Granada).Resumen
A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral
oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and
shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited
acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic
organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t1/2 = 183 min; 95%
removal rate after 24 h).