@misc{10481/81804,
year = {2023},
month = {3},
url = {https://hdl.handle.net/10481/81804},
abstract = {A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral
oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and
shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited
acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic
organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t1/2 = 183 min; 95%
removal rate after 24 h).},
organization = {MCIN/AEI	PID2020-113608RB-I00},
organization = {FEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades	P20_00672
P18-RT-612},
organization = {University of Granada	PPJIA2021.20},
organization = {Marie Sklodowska-Curie Individual Fellowship within the European Union H2020 programme	H2020-MSCA-IF-2019-EF-ST-888972-PSustMOF},
organization = {the European Union
H2020},
organization = {EU FEDER},
organization = {Garantía Juvenil en I+D+i, PEJ2018-004022-A},
organization = {Universidad
de Granada/CBUA},
organization = {Unidad de Excelencia de Química Aplicada a Biomedicina y
Medioambiente” (University of Granada).},
publisher = {ACS Publications},
title = {Oxime@Zirconium-Metal−Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning},
doi = {10.1021/acs.inorgchem.3c00121},
author = {González García, Lydia and Martín Romera, Javier David and Sánchez Sánchez, Purificación and Navarro, Jorge A. R. and Barea Martínez, Elisa María and Rodríguez Maldonado, Carmen and Carmona Fernández, Francisco Jesús},
}