Oxime@Zirconium-Metal−Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning González García, Lydia Martín Romera, Javier David Sánchez Sánchez, Purificación Navarro, Jorge A. R. Barea Martínez, Elisa María Rodríguez Maldonado, Carmen Carmona Fernández, Francisco Jesús A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t1/2 = 183 min; 95% removal rate after 24 h). 2023-05-25T08:33:53Z 2023-05-25T08:33:53Z 2023-03-20 info:eu-repo/semantics/article Inorg. Chem. 2023, 62, 5049−5053[https://doi.org/10.1021/acs.inorgchem.3c00121] https://hdl.handle.net/10481/81804 10.1021/acs.inorgchem.3c00121 eng info:eu-repo/grantAgreement/EC/H2020/MSCA-IF- 2019-EF-ST-888972-PSustMOF http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional ACS Publications