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Oxime@Zirconium-Metal−Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning

dc.contributor.authorGonzález García, Lydia 
dc.contributor.authorMartín Romera, Javier David 
dc.contributor.authorSánchez Sánchez, Purificación 
dc.contributor.authorNavarro, Jorge A. R.
dc.contributor.authorBarea Martínez, Elisa María 
dc.contributor.authorRodríguez Maldonado, Carmen 
dc.contributor.authorCarmona Fernández, Francisco Jesús 
dc.date.accessioned2023-05-25T08:33:53Z
dc.date.available2023-05-25T08:33:53Z
dc.date.issued2023-03-20
dc.identifier.citationInorg. Chem. 2023, 62, 5049−5053[https://doi.org/10.1021/acs.inorgchem.3c00121]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/81804
dc.description.abstractA novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (t1/2 = 183 min; 95% removal rate after 24 h).es_ES
dc.description.sponsorshipMCIN/AEI PID2020-113608RB-I00es_ES
dc.description.sponsorshipFEDER/Junta de Andalucia-Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades P20_00672 P18-RT-612es_ES
dc.description.sponsorshipUniversity of Granada PPJIA2021.20es_ES
dc.description.sponsorshipMarie Sklodowska-Curie Individual Fellowship within the European Union H2020 programme H2020-MSCA-IF-2019-EF-ST-888972-PSustMOFes_ES
dc.description.sponsorshipthe European Union H2020es_ES
dc.description.sponsorshipEU FEDERes_ES
dc.description.sponsorshipGarantía Juvenil en I+D+i, PEJ2018-004022-Aes_ES
dc.description.sponsorshipUniversidad de Granada/CBUAes_ES
dc.description.sponsorshipUnidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente” (University of Granada).es_ES
dc.language.isoenges_ES
dc.publisherACS Publicationses_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleOxime@Zirconium-Metal−Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoninges_ES
dc.typejournal articlees_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/MSCA-IF- 2019-EF-ST-888972-PSustMOFes_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1021/acs.inorgchem.3c00121
dc.type.hasVersionVoRes_ES


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