Compact Modeling of Two-Dimensional Field-Effect Biosensors
Metadata
Show full item recordAuthor
Pasadas Cantos, Francisco; El Grour, Tarek; González Marín, Enrique; Medina Rull, Alberto; Toral López, Alejandro; Cuesta López, Juan; García Ruiz, Francisco Javier; El Mir, Lassad; Godoy Medina, AndrésEditorial
MDPI
Materia
2D Biosensors Field-effect transistor Immunosensor Modeling MoS2 Sensor TMD Two-dimensional Verilog-A
Date
2023-02-07Referencia bibliográfica
Pasadas, F.; El Grour, T.; G. Marin, E.; Medina-Rull, A.; Toral-Lopez, A.; Cuesta-Lopez, J.; G. Ruiz, F.; El Mir, L.; Godoy, A. Compact Modeling of Two-Dimensional Field-Effect Biosensors. Sensors 2023, 23, 1840. [https://doi.org/10.3390/s23041840]
Sponsorship
Spanish Government MCIN/AEI/10.13039/501100011033 through the projects PID2020-116518GB-I00 and TED2021-129769B-I00 (MCIU/AEI/FEDER-UE); FEDER/Junta de Andalucía-Consejería de Transformacion Económica, Industria, Conocimiento y Universidades through the projects P20_00633 and A-TIC-646-UGR20; PAIDI 2020 and the European Social Fund Operational Programme 2014–2020 no. 208; MCIN/AEI/PTA grant, with reference PTA2020- 018250-I; FPU program FPU019/05132; Plan Propio of Universidad de GranadaAbstract
A compact model able to predict the electrical read-out of field-effect biosensors based on
two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the
electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of
the barrier oxide surface charge, and the Stern layer plus an ion-permeable membrane, all coupled
with the carrier transport inside the biosensor and solved by making use of the Donnan potential
inside the ion-permeable membrane formed by charged macromolecules. This electrostatics and
transport description account for the main surface-related physical and chemical processes that
impact the biosensor electrical performance, including the transport along the low-dimensional
channel in the diffusive regime, electrolyte screening, and the impact of biological charges. The
model is implemented in Verilog-A and can be employed on standard circuit design tools. The
theoretical predictions obtained with the model are validated against measurements of a MoS2
field-effect biosensor for streptavidin detection showing excellent agreement in all operation regimes
and leading the way for the circuit-level simulation of biosensors based on 2D semiconductors.