@misc{10481/81025,
year = {2023},
month = {2},
url = {https://hdl.handle.net/10481/81025},
abstract = {A compact model able to predict the electrical read-out of field-effect biosensors based on
two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the
electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of
the barrier oxide surface charge, and the Stern layer plus an ion-permeable membrane, all coupled
with the carrier transport inside the biosensor and solved by making use of the Donnan potential
inside the ion-permeable membrane formed by charged macromolecules. This electrostatics and
transport description account for the main surface-related physical and chemical processes that
impact the biosensor electrical performance, including the transport along the low-dimensional
channel in the diffusive regime, electrolyte screening, and the impact of biological charges. The
model is implemented in Verilog-A and can be employed on standard circuit design tools. The
theoretical predictions obtained with the model are validated against measurements of a MoS2
field-effect biosensor for streptavidin detection showing excellent agreement in all operation regimes
and leading the way for the circuit-level simulation of biosensors based on 2D semiconductors.},
organization = {Spanish Government MCIN/AEI/10.13039/501100011033
through the projects PID2020-116518GB-I00 and TED2021-129769B-I00 (MCIU/AEI/FEDER-UE)},
organization = {FEDER/Junta de Andalucía-Consejería de Transformacion Económica, Industria, Conocimiento
y Universidades through the projects P20_00633 and A-TIC-646-UGR20},
organization = {PAIDI 2020 and the European Social Fund Operational Programme 2014–2020 no. 208},
organization = {MCIN/AEI/PTA grant, with reference PTA2020-
018250-I},
organization = {FPU program FPU019/05132},
organization = {Plan Propio of Universidad de Granada},
publisher = {MDPI},
keywords = {2D},
keywords = {Biosensors},
keywords = {Field-effect transistor},
keywords = {Immunosensor},
keywords = {Modeling},
keywords = {MoS2},
keywords = {Sensor},
keywords = {TMD},
keywords = {Two-dimensional},
keywords = {Verilog-A},
title = {Compact Modeling of Two-Dimensional Field-Effect Biosensors},
doi = {10.3390/s23041840},
author = {Pasadas Cantos, Francisco and El Grour, Tarek and González Marín, Enrique and Medina Rull, Alberto and Toral López, Alejandro and Cuesta López, Juan and García Ruiz, Francisco Javier and El Mir, Lassad and Godoy Medina, Andrés},
}