Compact Modeling of Two-Dimensional Field-Effect Biosensors Pasadas Cantos, Francisco El Grour, Tarek González Marín, Enrique Medina Rull, Alberto Toral López, Alejandro Cuesta López, Juan García Ruiz, Francisco Javier El Mir, Lassad Godoy Medina, Andrés 2D Biosensors Field-effect transistor Immunosensor Modeling MoS2 Sensor TMD Two-dimensional Verilog-A A compact model able to predict the electrical read-out of field-effect biosensors based on two-dimensional (2D) semiconductors is introduced. It comprises the analytical description of the electrostatics including the charge density in the 2D semiconductor, the site-binding modeling of the barrier oxide surface charge, and the Stern layer plus an ion-permeable membrane, all coupled with the carrier transport inside the biosensor and solved by making use of the Donnan potential inside the ion-permeable membrane formed by charged macromolecules. This electrostatics and transport description account for the main surface-related physical and chemical processes that impact the biosensor electrical performance, including the transport along the low-dimensional channel in the diffusive regime, electrolyte screening, and the impact of biological charges. The model is implemented in Verilog-A and can be employed on standard circuit design tools. The theoretical predictions obtained with the model are validated against measurements of a MoS2 field-effect biosensor for streptavidin detection showing excellent agreement in all operation regimes and leading the way for the circuit-level simulation of biosensors based on 2D semiconductors. 2023-04-12T11:25:33Z 2023-04-12T11:25:33Z 2023-02-07 info:eu-repo/semantics/article Pasadas, F.; El Grour, T.; G. Marin, E.; Medina-Rull, A.; Toral-Lopez, A.; Cuesta-Lopez, J.; G. Ruiz, F.; El Mir, L.; Godoy, A. Compact Modeling of Two-Dimensional Field-Effect Biosensors. Sensors 2023, 23, 1840. [https://doi.org/10.3390/s23041840] https://hdl.handle.net/10481/81025 10.3390/s23041840 eng http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional MDPI