Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health
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Ortiz Sandoval, Pilar; Torres Sánchez, Alfonso; López Moreno, Ana; Cerk, Klara; Ruiz Moreno, Ángel; Monteoliva Sánchez, Mercedes; Ampatzoglou, Antonios; Aguilera Gómez, Margarita; Gruszecka-Kosowska, Agnieszka MalgorzataEditorial
MDPI
Materia
Xenobiotic Risk assessment Farm to fork strategy ADME approach Microbiome
Date
2022-03-17Referencia bibliográfica
Ortiz, P... [et al.]. Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health. J. Xenobiot. 2022, 12, 56–63. [https://doi.org/10.3390/jox12010006]
Abstract
Chemical risk assessment in the context of the risk analysis framework was initially
designed to evaluate the impact of hazardous substances or xenobiotics on human health. As the
need of multiple stressors assessment was revealed to be more reliable regarding the occurrence
and severity of the adverse effects in the exposed organisms, the cumulative risk assessment started
to be the recommended approach. As toxicant mixtures and their “cocktail effects” are considered
to be main hazards, the most important exposure for these xenobiotics would be of dietary and
environmental origin. In fact, even a more holistic prism should currently be considered. In this
sense, the definition of One Health refers to simultaneous actions for improving human, animal, and
environmental health through transdisciplinary cooperation. Global policies necessitate going beyond
the classical risk assessment for guaranteeing human health through actions and implementation
of the One Health approach. In this context, a new perspective is proposed for the integration of
microbiome biomarkers and next generation probiotics potentially impacting and modulating not
only human health, but plant, animal health, and the environment.