Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health Ortiz Sandoval, Pilar Torres Sánchez, Alfonso López Moreno, Ana Cerk, Klara Ruiz Moreno, Ángel Monteoliva Sánchez, Mercedes Ampatzoglou, Antonios Aguilera Gómez, Margarita Gruszecka-Kosowska, Agnieszka Malgorzata Xenobiotic Risk assessment Farm to fork strategy ADME approach Microbiome Chemical risk assessment in the context of the risk analysis framework was initially designed to evaluate the impact of hazardous substances or xenobiotics on human health. As the need of multiple stressors assessment was revealed to be more reliable regarding the occurrence and severity of the adverse effects in the exposed organisms, the cumulative risk assessment started to be the recommended approach. As toxicant mixtures and their “cocktail effects” are considered to be main hazards, the most important exposure for these xenobiotics would be of dietary and environmental origin. In fact, even a more holistic prism should currently be considered. In this sense, the definition of One Health refers to simultaneous actions for improving human, animal, and environmental health through transdisciplinary cooperation. Global policies necessitate going beyond the classical risk assessment for guaranteeing human health through actions and implementation of the One Health approach. In this context, a new perspective is proposed for the integration of microbiome biomarkers and next generation probiotics potentially impacting and modulating not only human health, but plant, animal health, and the environment. 2022-04-18T11:12:07Z 2022-04-18T11:12:07Z 2022-03-17 info:eu-repo/semantics/article Ortiz, P... [et al.]. Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health. J. Xenobiot. 2022, 12, 56–63. [https://doi.org/10.3390/jox12010006] http://hdl.handle.net/10481/74326 10.3390/jox12010006 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI