@misc{10481/74326,
year = {2022},
month = {3},
url = {http://hdl.handle.net/10481/74326},
abstract = {Chemical risk assessment in the context of the risk analysis framework was initially
designed to evaluate the impact of hazardous substances or xenobiotics on human health. As the
need of multiple stressors assessment was revealed to be more reliable regarding the occurrence
and severity of the adverse effects in the exposed organisms, the cumulative risk assessment started
to be the recommended approach. As toxicant mixtures and their “cocktail effects” are considered
to be main hazards, the most important exposure for these xenobiotics would be of dietary and
environmental origin. In fact, even a more holistic prism should currently be considered. In this
sense, the definition of One Health refers to simultaneous actions for improving human, animal, and
environmental health through transdisciplinary cooperation. Global policies necessitate going beyond
the classical risk assessment for guaranteeing human health through actions and implementation
of the One Health approach. In this context, a new perspective is proposed for the integration of
microbiome biomarkers and next generation probiotics potentially impacting and modulating not
only human health, but plant, animal health, and the environment.},
publisher = {MDPI},
keywords = {Xenobiotic},
keywords = {Risk assessment},
keywords = {Farm to fork strategy},
keywords = {ADME approach},
keywords = {Microbiome},
title = {Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health},
doi = {10.3390/jox12010006},
author = {Ortiz Sandoval, Pilar and Torres Sánchez, Alfonso and López Moreno, Ana and Cerk, Klara and Ruiz Moreno, Ángel and Monteoliva Sánchez, Mercedes and Ampatzoglou, Antonios and Aguilera Gómez, Margarita and Gruszecka-Kosowska, Agnieszka Malgorzata},
}