Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea
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AuthorÁlvarez Caballero, Juan Manuel; Cuca Suárez, Luis Enrique; Coy Barrera, Ericsson; Olmo García, Lucía; García, Jesús; Cruz, Mercedes de la; Perez Victoria, Ignacio; Reyes, Fernando; Carrasco Pancorbo, Lucía
ACS Omega 2021, 6, 48, 32631–32636. [https://doi.org/10.1021/acsomega.1c04255]
SponsorshipFundación MEDINA; Universidad Nacional de Colombia; Universidad del Magdalena proyecto VIN2016225; UMNG proyecto IMP-CIAS-2924
Two undescribed 4′-O-methylkaempferol-[3″,4″-di-p-coumaroyl]-α-l-rhamnopyranosides, caerulines A and B (1-2), along with three known 4′-O-methylkaempferol diacylrhamnosides isomers (3-5) were isolated from an ethanol extract of the leaves of Persea caerulea, a native plant growing on the Colombian Caribbean coast. The chemical structures of 1 and 2 were elucidated by spectroscopic methods. The effect of compounds 1-5 against four pathogenic microorganisms [i.e., methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, Candida albicans, and Aspergillus fumigatus] was tested in vitro. The compounds exhibited no activity against these pathogens except MRSA (MIC 12-48 μg/mL). Caeruline B (2) was found to be the most active compound with a modest anti-MRSA activity (MIC = 12 μg/mL).