Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea Álvarez Caballero, Juan Manuel Cuca Suárez, Luis Enrique Coy Barrera, Ericsson Olmo García, Lucía García, Jesús Cruz, Mercedes de la Perez Victoria, Ignacio Reyes, Fernando Carrasco Pancorbo, Lucía The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. Two undescribed 4′-O-methylkaempferol-[3″,4″-di-p-coumaroyl]-α-l-rhamnopyranosides, caerulines A and B (1-2), along with three known 4′-O-methylkaempferol diacylrhamnosides isomers (3-5) were isolated from an ethanol extract of the leaves of Persea caerulea, a native plant growing on the Colombian Caribbean coast. The chemical structures of 1 and 2 were elucidated by spectroscopic methods. The effect of compounds 1-5 against four pathogenic microorganisms [i.e., methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, Candida albicans, and Aspergillus fumigatus] was tested in vitro. The compounds exhibited no activity against these pathogens except MRSA (MIC 12-48 μg/mL). Caeruline B (2) was found to be the most active compound with a modest anti-MRSA activity (MIC = 12 μg/mL). 2021-12-20T11:45:22Z 2021-12-20T11:45:22Z 2021-11-23 journal article ACS Omega 2021, 6, 48, 32631–32636. [https://doi.org/10.1021/acsomega.1c04255] http://hdl.handle.net/10481/72133 10.1021/acsomega.1c04255 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España ACS