Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
Metadatos
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Moleón González, María del Carmen; Martínez Gómez, Estrella; Flook, Marisa; Peralta-Leal, Andreína; Gallego, Juan Antonio; Sánchez Gómez, Hortensia; Alharilla Montilla Ibáñez, Maria de; Dominguez Durán, Emilio; Soto Varela, Andrés; Aran, Ismael; Frejo, Lidia; López Escámez, José AntonioEditorial
MDPI
Materia
Hearing loss Vértigo Migraine Cytokines Inflammation Vestibular disorders
Fecha
2021Referencia bibliográfica
Moleon, M.-D.-C.; Martinez-Gomez, E.; Flook, M.; Peralta-Leal, A.; Gallego, J.A.; Sanchez-Gomez, H.; Montilla-Ibañez, M.A.; Dominguez-Durán, E.; Soto-Varela, A.; Aran, I.; et al. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052. https:// doi.org/10.3390/jcm10184052
Patrocinador
ISCIII and European Regional Funds (Grants PI17/01644 and PI20/01126); Andalusian Health Government (Grant PE-0356-2018).; Andalusian Health Government (Grant PI-0027-2020).Resumen
Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities
such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in
MD according to the age of onset of the condition. Methods: A cross-sectional study including
83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD,
>50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and
cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the
different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls.
Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels
were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004)
and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have
a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile
in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with
MD or migraine and controls.