@misc{10481/70909,
year = {2021},
url = {http://hdl.handle.net/10481/70909},
abstract = {Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities
such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in
MD according to the age of onset of the condition. Methods: A cross-sectional study including
83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD,
>50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and
cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the
different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls.
Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels
were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004)
and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have
a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile
in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with
MD or migraine and controls.},
organization = {ISCIII and European Regional Funds (Grants PI17/01644
and PI20/01126)},
organization = {Andalusian Health Government (Grant PE-0356-2018).},
organization = {Andalusian Health Government (Grant PI-0027-2020).},
publisher = {MDPI},
keywords = {Hearing loss},
keywords = {Vértigo},
keywords = {Migraine},
keywords = {Cytokines},
keywords = {Inflammation},
keywords = {Vestibular disorders},
title = {Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease},
doi = {10.3390/jcm10184052},
author = {Moleón González, María del Carmen and Martínez Gómez, Estrella and Flook, Marisa and Peralta-Leal, Andreína and Gallego, Juan Antonio and Sánchez Gómez, Hortensia and Alharilla Montilla Ibáñez, Maria de and Dominguez Durán, Emilio and Soto Varela, Andrés and Aran, Ismael and Frejo, Lidia and López Escámez, José Antonio},
}