Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease Moleón González, María del Carmen Martínez Gómez, Estrella Flook, Marisa Peralta-Leal, Andreína Gallego, Juan Antonio Sánchez Gómez, Hortensia Alharilla Montilla Ibáñez, Maria de Dominguez Durán, Emilio Soto Varela, Andrés Aran, Ismael Frejo, Lidia López Escámez, José Antonio Hearing loss Vértigo Migraine Cytokines Inflammation Vestibular disorders Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls. 2021-10-18T07:03:19Z 2021-10-18T07:03:19Z 2021 info:eu-repo/semantics/article Moleon, M.-D.-C.; Martinez-Gomez, E.; Flook, M.; Peralta-Leal, A.; Gallego, J.A.; Sanchez-Gomez, H.; Montilla-Ibañez, M.A.; Dominguez-Durán, E.; Soto-Varela, A.; Aran, I.; et al. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052. https:// doi.org/10.3390/jcm10184052 http://hdl.handle.net/10481/70909 10.3390/jcm10184052 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI