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dc.contributor.authorMoleon, María del Carmen
dc.contributor.authorMartínez Gómez, Estrella
dc.contributor.authorFlook, Marisa
dc.contributor.authorPeralta-Leal, Andreína
dc.contributor.authorGallego, Juan Antonio
dc.contributor.authorSánchez Gómez, Hortensia
dc.contributor.authorAlharilla Montilla Ibáñez, Maria de
dc.contributor.authorDominguez Durán, Emilio
dc.contributor.authorSoto Varela, Andrés
dc.contributor.authorAran, Ismael
dc.contributor.authorFrejo, Lidia
dc.contributor.authorLópez Escámez, José Antonio
dc.identifier.citationMoleon, M.-D.-C.; Martinez-Gomez, E.; Flook, M.; Peralta-Leal, A.; Gallego, J.A.; Sanchez-Gomez, H.; Montilla-Ibañez, M.A.; Dominguez-Durán, E.; Soto-Varela, A.; Aran, I.; et al. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052. https://
dc.description.abstractBackground: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.es_ES
dc.description.sponsorshipISCIII and European Regional Funds (Grants PI17/01644 and PI20/01126)es_ES
dc.description.sponsorshipAndalusian Health Government (Grant PE-0356-2018).es_ES
dc.description.sponsorshipAndalusian Health Government (Grant PI-0027-2020).es_ES
dc.rightsAtribución 3.0 España*
dc.subjectHearing losses_ES
dc.subjectVértigo es_ES
dc.subjectCytokines es_ES
dc.subjectInflammation es_ES
dc.subjectVestibular disorderses_ES
dc.titleClinical and Cytokine Profile in Patients with Early and Late Onset Meniere Diseasees_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España