Relationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbena
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AuthorSánchez Marzo, Noelia; Lozano Sánchez, Jesús; Cádiz Gurrea, María de la Luz; Herranz-López, María; Micol Molina, Vicente; Segura Carretero, Antonio
Lemon verbenaRP-HPLC-ESI-TOF-MSSemi-preparative chromatographyIsolationAntioxidantStructure-activity relationship
Sánchez-Marzo, N.; Lozano-Sánchez, J.; Cádiz-Gurrea, M.L.; Herranz-López, M.; Micol, V.; Segura-Carretero, A. Relationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbena. Antioxidants 2019, 8, 324 [doi:10.3390/antiox8080324]
SponsorshipThis work was funded by projects AGL2015-67995-C3-2-R, RTI2018-096724-B-C21 and RTI2018-096724-B-C22 from Spanish Ministry of Economy and Competitiveness and P11-CTS-7625 from Andalusian Regional Government Council of Innovation and Science. We also thank projects and scholarships from the Generalitat Valenciana (PROMETEO/2016/006, ACIF/2016/230 and APOSTD/2017/023) and grant from CIBER (CB12/03/30038, Fisiopatologia de la Obesidad y la Nutricion, CIBERobn, Instituto de Salud Carlos III).
Over the last few years, people have been concerned about the narrow relationship between nutrition and health leading to an increasing demand of nutraceutical products and functional food. Lemon verbena (Lippia citriodora Kunth) has been traditionally used for respiratory, digestive, and muscular diseases, showing effects that are promoted by the antioxidant activity of its phytoconstituents. The antioxidant power of several lemon verbena extracts has been tested but its isolated compounds activity has not been described. The aim of the present work was to isolate phytochemicals from a commercial lemon verbena extract through a semi-preparative high-performance liquid chromatography approach for further evaluation of its individual antioxidant activity using three different methods. The structure-antioxidant activity relationships revealed the influence of substitutions in the strong antioxidant power exerted by glycosylated phenylpropanoids, in contrast to the low antioxidant capacity showed by iridoids. Development of enriched extracts in these compounds could lead to greater antioxidant effects and improved functional ingredients to prevent chronic diseases.