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dc.contributor.authorSánchez Marzo, Noelia
dc.contributor.authorLozano Sánchez, Jesús 
dc.contributor.authorCádiz Gurrea, María de la Luz 
dc.contributor.authorHerranz-López, María
dc.contributor.authorMicol Molina, Vicente
dc.contributor.authorSegura Carretero, Antonio
dc.identifier.citationSánchez-Marzo, N.; Lozano-Sánchez, J.; Cádiz-Gurrea, M.L.; Herranz-López, M.; Micol, V.; Segura-Carretero, A. Relationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbena. Antioxidants 2019, 8, 324 [doi:10.3390/antiox8080324]es_ES
dc.descriptionThe following are available online at, Figure S1. UV chromatograms at 280 nm and MS spectra for (A) peak 5 and (B) peak 28; Figure S2. Base peak chromatograms of the collected fractions from a commercial lemon verbena extract (PLX®10) and MS spectra of their major compound, including the peak numbers of Table 1; Table S1. In vitro antioxidant activity by FRAP, TEAC and ORAC assays for the commercial lemon verbena extract (PLX®10) and its collected fractions, expressed as the mean of three independent replicates ± the standard deviation.es_ES
dc.description.abstractOver the last few years, people have been concerned about the narrow relationship between nutrition and health leading to an increasing demand of nutraceutical products and functional food. Lemon verbena (Lippia citriodora Kunth) has been traditionally used for respiratory, digestive, and muscular diseases, showing effects that are promoted by the antioxidant activity of its phytoconstituents. The antioxidant power of several lemon verbena extracts has been tested but its isolated compounds activity has not been described. The aim of the present work was to isolate phytochemicals from a commercial lemon verbena extract through a semi-preparative high-performance liquid chromatography approach for further evaluation of its individual antioxidant activity using three different methods. The structure-antioxidant activity relationships revealed the influence of substitutions in the strong antioxidant power exerted by glycosylated phenylpropanoids, in contrast to the low antioxidant capacity showed by iridoids. Development of enriched extracts in these compounds could lead to greater antioxidant effects and improved functional ingredients to prevent chronic diseases.es_ES
dc.description.sponsorshipThis work was funded by projects AGL2015-67995-C3-2-R, RTI2018-096724-B-C21 and RTI2018-096724-B-C22 from Spanish Ministry of Economy and Competitiveness and P11-CTS-7625 from Andalusian Regional Government Council of Innovation and Science. We also thank projects and scholarships from the Generalitat Valenciana (PROMETEO/2016/006, ACIF/2016/230 and APOSTD/2017/023) and grant from CIBER (CB12/03/30038, Fisiopatologia de la Obesidad y la Nutricion, CIBERobn, Instituto de Salud Carlos III).es_ES
dc.rightsAtribución 3.0 España*
dc.subjectLemon verbenaes_ES
dc.subjectSemi-preparative chromatographyes_ES
dc.subjectStructure-activity relationshipes_ES
dc.titleRelationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbenaes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España