Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products
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MangoBy-productsAntiplatelet activityBioactive compoundsHPLC-DAD-q-TOF-MS
Alañón, M. E., Palomo, I., Rodríguez, L., Fuentes, E., Arráez-Román, D., & Segura-Carretero, A. (2019). Antiplatelet activity of natural bioactive extracts from mango (Mangifera indica L.) and its by-products. Antioxidants, 8(11), 517.
SponsorshipIbero-American Program of Science and Technology for Development, Red iberoamericana de aprovechamiento integral de alimentos autóctonos subutilizados (ALSUB-CYTED, 118RT0543). Financial support of projects from program of aid for R + D + i of the Andalusian plan for research, development and innovation (PAIDI 2020) of Junta de Andalucía and Junta de Comunidades de Castilla-La Mancha (SBPLY/17/180501/000509).
The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5’-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments.