Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products Alañón, María Elena Arráez Román, David Segura Carretero, Antonio Mango By-products Antiplatelet activity Bioactive compounds HPLC-DAD-q-TOF-MS The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5’-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments. 2020-01-08T13:52:38Z 2020-01-08T13:52:38Z 2019-10-29 info:eu-repo/semantics/article Alañón, M. E., Palomo, I., Rodríguez, L., Fuentes, E., Arráez-Román, D., & Segura-Carretero, A. (2019). Antiplatelet activity of natural bioactive extracts from mango (Mangifera indica L.) and its by-products. Antioxidants, 8(11), 517. http://hdl.handle.net/10481/58545 10.3390/antiox8110517 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI