Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program
Metadatos
Mostrar el registro completo del ítemAutor
Muñoz Dorado, José; Moraleda Muñoz, Aurelio; Marcos Torres, Francisco Javier; Contreras Moreno, Francisco Javier; Pérez Torres, JuanaEditorial
eLife Sciences Publications
Fecha
2019-10-14Referencia bibliográfica
Muñoz-Dorado, J., Moraleda-Muñoz, A., Marcos-Torres, F. J., Contreras-Moreno, F. J., Martin-Cuadrado, A. B., Schrader, J. M., ... & Pérez, J. (2019). Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program. eLife, 8.
Patrocinador
This work has been supported by the Spanish Government (grants CSD2009-00006 to JMD and BFU2016-75425-P to AMM [70% funded by FEDER]), and by NIGMS of the National Institutes of Health under award number R35GM124733 to JMS. JPT and JMD were granted with fellowships of the Salvador de Madariaga Program to stay at Wayne State University for four months. PIH was funded by a grant from NSF IOS 1651921. We also want to thank Prof. Lee Kroos for providing strains.Resumen
The bacterium Myxococcus xanthus exhibits a complex multicellular life cycle. In the
presence of nutrients, cells prey cooperatively. Upon starvation, they enter a developmental cycle
wherein cells aggregate to produce macroscopic fruiting bodies filled with resistant myxospores.
We used RNA-Seq technology to examine the transcriptome of the 96 hr developmental program.
These data revealed that 1415 genes were sequentially expressed in 10 discrete modules, with
expression peaking during aggregation, in the transition from aggregation to sporulation, or during
sporulation. Analysis of genes expressed at each specific time point provided insights as to how
starving cells obtain energy and precursors necessary for assembly of fruiting bodies and into
developmental production of secondary metabolites. This study offers the first global view of
developmental transcriptional profiles and provides important tools and resources for future
studies.