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dc.contributor.authorMuñoz Dorado, José 
dc.contributor.authorMoraleda Muñoz, Aurelio 
dc.contributor.authorMarcos Torres, Francisco Javier
dc.contributor.authorContreras Moreno, Francisco Javier
dc.contributor.authorPérez, Juana
dc.identifier.citationMuñoz-Dorado, J., Moraleda-Muñoz, A., Marcos-Torres, F. J., Contreras-Moreno, F. J., Martin-Cuadrado, A. B., Schrader, J. M., ... & Pérez, J. (2019). Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program. eLife, 8.es_ES
dc.description.abstractThe bacterium Myxococcus xanthus exhibits a complex multicellular life cycle. In the presence of nutrients, cells prey cooperatively. Upon starvation, they enter a developmental cycle wherein cells aggregate to produce macroscopic fruiting bodies filled with resistant myxospores. We used RNA-Seq technology to examine the transcriptome of the 96 hr developmental program. These data revealed that 1415 genes were sequentially expressed in 10 discrete modules, with expression peaking during aggregation, in the transition from aggregation to sporulation, or during sporulation. Analysis of genes expressed at each specific time point provided insights as to how starving cells obtain energy and precursors necessary for assembly of fruiting bodies and into developmental production of secondary metabolites. This study offers the first global view of developmental transcriptional profiles and provides important tools and resources for future studies.es_ES
dc.description.sponsorshipThis work has been supported by the Spanish Government (grants CSD2009-00006 to JMD and BFU2016-75425-P to AMM [70% funded by FEDER]), and by NIGMS of the National Institutes of Health under award number R35GM124733 to JMS. JPT and JMD were granted with fellowships of the Salvador de Madariaga Program to stay at Wayne State University for four months. PIH was funded by a grant from NSF IOS 1651921. We also want to thank Prof. Lee Kroos for providing strains.es_ES
dc.publishereLife Sciences Publicationses_ES
dc.rightsAtribución 3.0 España*
dc.titleTranscriptome dynamics of the Myxococcus xanthus multicellular developmental programes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España