@misc{10481/57600,
year = {2019},
month = {10},
url = {http://hdl.handle.net/10481/57600},
abstract = {The bacterium Myxococcus xanthus exhibits a complex multicellular life cycle. In the
presence of nutrients, cells prey cooperatively. Upon starvation, they enter a developmental cycle
wherein cells aggregate to produce macroscopic fruiting bodies filled with resistant myxospores.
We used RNA-Seq technology to examine the transcriptome of the 96 hr developmental program.
These data revealed that 1415 genes were sequentially expressed in 10 discrete modules, with
expression peaking during aggregation, in the transition from aggregation to sporulation, or during
sporulation. Analysis of genes expressed at each specific time point provided insights as to how
starving cells obtain energy and precursors necessary for assembly of fruiting bodies and into
developmental production of secondary metabolites. This study offers the first global view of
developmental transcriptional profiles and provides important tools and resources for future
studies.},
organization = {This work has been supported by the Spanish Government (grants CSD2009-00006 to JMD and
BFU2016-75425-P to AMM [70% funded by FEDER]), and by NIGMS of the National Institutes of
Health under award number R35GM124733 to JMS. JPT and JMD were granted with fellowships of
the Salvador de Madariaga Program to stay at Wayne State University for four months. PIH was
funded by a grant from NSF IOS 1651921. We also want to thank Prof. Lee Kroos for providing
strains.},
publisher = {eLife Sciences Publications},
title = {Transcriptome dynamics of the Myxococcus xanthus multicellular developmental program},
doi = {10.7554/eLife.50374},
author = {Muñoz Dorado, José and Moraleda Muñoz, Aurelio and Marcos Torres, Francisco Javier and Contreras Moreno, Francisco Javier and Pérez Torres, Juana},
}