Selective One-Pot Two-Step C-C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts

Cirujano, Francisco G.; López-Maya, Elena; Rodríguez-Albelo, Luisa Marleny; Barea Martínez, Elisa María; Rodríguez Navarro, Jorge Andrés; De Vos, Dirk E

doi:10.1002/cctc.201700784

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Identificadores

URI: https://hdl.handle.net/10481/111009

DOI: 10.1002/cctc.201700784

ISSN: 1867-3899

ISSN: 1867-3880

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Editorial

Wiley

Materia

Tunable basicity

C-C bond formation

Heterogeneous catalysis

Fecha

2017-06-19

Referencia bibliográfica

Cirujano, F. G.; López-Maya, E.; Rodríguez-Albelo, L. M. [et al]. (2017). Selective One-Pot Two-Step C–C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts. ChemCatChem, Volume 9, issue 21, pp. 4019 – 4023. https://doi.org/10.1002/cctc.201700784

Patrocinador

Universidad de Granada (Dpto de Química Inorgánica); Spanish Ministry of Economy and Competitiveness (CTQ2014-53486-R); Fonds Wetenschappelijk Onderzoek (G.0256.14N); Horizon 2020, Marie Sklodowska–Curie (750391, project acronym SINMOF)

Resumen

Copper-ion-exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one-pot, two-step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity of multifunctional metal–organic framework catalysts through ion exchange with copper(- II) cations allows the tandem C@C bond-forming process to be selectively directed towards the desired pharmaceutical intermediate.

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