Selective One-Pot Two-Step C-C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts Cirujano, Francisco G. López-Maya, Elena Rodríguez-Albelo, Luisa Marleny Barea Martínez, Elisa María Rodríguez Navarro, Jorge Andrés De Vos, Dirk E Tunable basicity C-C bond formation Heterogeneous catalysis Spanish Ministry of Economy and Competitiveness (MINECO) under the grant number CTQ2014-53486-R, Fonds Wetenschappelijk Onderzoek (F.W.O). for project funding under the grant number G.0256.14N and the European Commission-Horizon 2020 under the Marie Sklodowska–Curie Individual Fellowship grant agreement number750391(Project acronym SINMOF) are acknowledged for financial support. Copper-ion-exchanged nickel pyrazolate frameworks behave as selective heterogeneous catalysts for the one-pot, two-step (Henry reaction/Michael type addition) synthesis of neuroactive pharmaceutical intermediates starting from nitromethane and benzaldehyde. Tuning the basicity of multifunctional metal–organic framework catalysts through ion exchange with copper(- II) cations allows the tandem C@C bond-forming process to be selectively directed towards the desired pharmaceutical intermediate. 2026-02-16T08:41:10Z 2026-02-16T08:41:10Z 2017-06-19 journal article Cirujano, F. G.; López-Maya, E.; Rodríguez-Albelo, L. M. [et al]. (2017). Selective One-Pot Two-Step C–C Bond Formation using Metal–Organic Frameworks with Mild Basicity as Heterogeneous Catalysts. ChemCatChem, Volume 9, issue 21, pp. 4019 – 4023. https://doi.org/10.1002/cctc.201700784 1867-3899 1867-3880 https://hdl.handle.net/10481/111009 10.1002/cctc.201700784 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Wiley