The role of palmitoylation in regulating Ras localization and function

Eisenberg, Sharon; Laude, Alex J.; Beckett, Alison J.; Mageean, Craig J.; Aran, Verónica; Hernández Valladares, María del Carmen; Henis, Yoav I.; Prior, Ian A.

doi:10.1042/BST20120268

bst0410079.pdf (458.8Kb)

Identificadores

URI: https://hdl.handle.net/10481/109760

DOI: 10.1042/BST20120268

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Editorial

Portland Press

Materia

Compartmentization

Nanocluster

Palmitoylation

RAS

Fecha

2013-02-01

Referencia bibliográfica

Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis, Ian A. Prior; The role of palmitoylation in regulating Ras localization and function. Biochem Soc Trans 1 February 2013; 41 (1): 79–83. doi: https://doi.org/10.1042/BST20120268

Patrocinador

Royal Society; North West Cancer Research Fund; Wellcome Trust; DGF-DIP [KL 1948/1-1, GA 309/10-1]; Ministry of Science & Technology, Israel

Resumen

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

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