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The role of palmitoylation in regulating Ras localization and function

dc.contributor.authorEisenberg, Sharon
dc.contributor.authorLaude, Alex J.
dc.contributor.authorBeckett, Alison J.
dc.contributor.authorMageean, Craig J.
dc.contributor.authorAran, Verónica
dc.contributor.authorHernández Valladares, María del Carmen
dc.contributor.authorHenis, Yoav I.
dc.contributor.authorPrior, Ian A.
dc.date.accessioned2026-01-15T13:00:47Z
dc.date.available2026-01-15T13:00:47Z
dc.date.issued2013-02-01
dc.identifier.citationSharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis, Ian A. Prior; The role of palmitoylation in regulating Ras localization and function. Biochem Soc Trans 1 February 2013; 41 (1): 79–83. doi: https://doi.org/10.1042/BST20120268es_ES
dc.identifier.urihttps://hdl.handle.net/10481/109760
dc.descriptionWe gratefully acknowledge funding from the Royal Society, North West Cancer Research Fund, the Wellcome Trust (to I.A.P.) and from the DGF-DIP [grant numbers KL 1948/1-1 and GA 309/10-1] and the Ministry of Science & Technology, Israel (to Y.I.H.). Y.I.H. is an incumbent of the Zalman Weinberg Chair in Cell Biology.es_ES
dc.description.abstractRas GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.es_ES
dc.description.sponsorshipRoyal Societyes_ES
dc.description.sponsorshipNorth West Cancer Research Fundes_ES
dc.description.sponsorshipWellcome Trustes_ES
dc.description.sponsorshipDGF-DIP [KL 1948/1-1, GA 309/10-1]es_ES
dc.description.sponsorshipMinistry of Science & Technology, Israeles_ES
dc.language.isoenges_ES
dc.publisherPortland Presses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCompartmentizationes_ES
dc.subjectNanoclusteres_ES
dc.subjectPalmitoylationes_ES
dc.subjectRASes_ES
dc.titleThe role of palmitoylation in regulating Ras localization and functiones_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doi10.1042/BST20120268
dc.type.hasVersionVoRes_ES


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