The role of palmitoylation in regulating Ras localization and function Eisenberg, Sharon Laude, Alex J. Beckett, Alison J. Mageean, Craig J. Aran, Verónica Hernández Valladares, María del Carmen Henis, Yoav I. Prior, Ian A. Compartmentization Nanocluster Palmitoylation RAS We gratefully acknowledge funding from the Royal Society, North West Cancer Research Fund, the Wellcome Trust (to I.A.P.) and from the DGF-DIP [grant numbers KL 1948/1-1 and GA 309/10-1] and the Ministry of Science & Technology, Israel (to Y.I.H.). Y.I.H. is an incumbent of the Zalman Weinberg Chair in Cell Biology. Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras. 2026-01-15T13:00:47Z 2026-01-15T13:00:47Z 2013-02-01 journal article Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis, Ian A. Prior; The role of palmitoylation in regulating Ras localization and function. Biochem Soc Trans 1 February 2013; 41 (1): 79–83. doi: https://doi.org/10.1042/BST20120268 https://hdl.handle.net/10481/109760 10.1042/BST20120268 eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 Internacional Portland Press