Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren
Metadatos
Mostrar el registro completo del ítemAutor
Ramírez, Viviana; González-Palacios, Patricia; González Domenech, Pablo José; Jaimez-Pérez, Sonia; Baca, Miguel A.; Rodrigo Conde Salazar, Lourdes T.; Álvarez Cubero, María Jesús; Monteagudo Sánchez, Celia; Martínez González, Luis Javier; Rivas Velasco, Ana MaríaEditorial
MDPI
Materia
Cognitive function Neurodevelopmental disorders Genetic polymorphism
Fecha
2024-08-10Referencia bibliográfica
Ramírez, V.; González- Palacios, P.; González-Domenech, P.J.; Jaimez-Pérez, S.; Baca,M.A.; Rodrigo, L.; Álvarez-Cubero,M.J.;Monteagudo, C.; Martínez-González, L.J.; Rivas, A. Influence of Genetic Polymorphisms on Cognitive Function According to Dietary Exposure to Bisphenols in a Sample of Spanish Schoolchildren. Nutrients 2024, 16, 2639. https://doi.org/10.3390/nu16162639
Patrocinador
Instituto de Salud Carlos III (ISCIII) through the project “PI23/01359” and co-funded by the European UnionResumen
Background: Neurodevelopmental disorders (NDDs) like intellectual disability (ID) are
highly heritable, but the environment plays an important role. For example, endocrine disrupting
chemicals (EDCs), including bisphenol A (BPA) and its analogues, have been termed neuroendocrine
disruptors. This study aimed to evaluate the influence of different genetic polymorphisms (SNPs)
on cognitive function in Spanish schoolchildren according to dietary bisphenol exposure. Methods:
A total of 102 children aged 6–12 years old were included. Ten SNPs in genes involved in brain
development, synaptic plasticity, and neurotransmission (BDNF, NTRK2, HTR2A, MTHFR, OXTR,
SLC6A2, and SNAP25) were genotyped. Then, dietary exposure to bisphenols (BPA plus BPS) was
estimated and cognitive functions were assessed using the WISC-V Spanish form. Results: BDNF
rs11030101-T and SNAP25 rs363039-A allele carriers scored better on the fluid reasoning domain,
except for those inheriting the BDNF rs6265-A allele, who had lower scores. Secondly, relevant
SNP–bisphenol interactions existed in verbal comprehension (NTRK2 rs10868235 (p-int = 0.043)),
working memory (HTR2A rs7997012 (p-int = 0.002), MTHFR rs1801133 (p-int = 0.026), and OXTR
rs53576 (p-int = 0.030)) and fluid reasoning (SLC6A2 rs998424 (p-int = 0.004)). Conclusions: Our
findings provide the first proof that exploring the synergistic or additive effects between genetic
variability and bisphenol exposure on cognitive function could lead to a better understanding of the
multifactorial and polygenic aetiology of NDDs.