A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces
Metadatos
Afficher la notice complèteEditorial
Royal Society of Chemistry
Date
2024-02-07Referencia bibliográfica
Braun, Josef, et al. A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces. Org. Biomol. Chem., 2024, 22, 1998–2002 [10.1039/d4ob00014e]
Patrocinador
Doctoral fellowship of the Foundation of German Business; Merck Future Insight Prize 2020; EC (H2020-MSCA–IF–2018-841990); EPSRC (EP/S010289/1); EU H2020 (grant agreement no 823717 – ESTEEM3)Résumé
Surface-adhered bacteria on implants represent a major challenge
for antibiotic treatment. We introduce hydrogel-coated surfaces
loaded with tailored Pd-nanosheets which catalyze the release of
antibiotics from inactive prodrugs. Masked and antibiotically
inactive fluoroquinolone analogs were efficiently activated at the
surface and prevented the formation of Staphylococcus aureus
biofilms.