A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces Braun, Josef Ortega Liébana, M. Carmen Unciti-Broceta, Asier Sieber, Stephan A. Surface-adhered bacteria on implants represent a major challenge for antibiotic treatment. We introduce hydrogel-coated surfaces loaded with tailored Pd-nanosheets which catalyze the release of antibiotics from inactive prodrugs. Masked and antibiotically inactive fluoroquinolone analogs were efficiently activated at the surface and prevented the formation of Staphylococcus aureus biofilms. 2024-06-19T08:18:57Z 2024-06-19T08:18:57Z 2024-02-07 info:eu-repo/semantics/article Braun, Josef, et al. A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces. Org. Biomol. Chem., 2024, 22, 1998–2002 [10.1039/d4ob00014e] https://hdl.handle.net/10481/92697 10.1039/d4ob00014e eng info:eu-repo/grantAgreement/EC/H2020/MSCA 841990 info:eu-repo/grantAgreement/EC/H2020/823717 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional Royal Society of Chemistry