Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes
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Sánchez Lara, Eduardo; Favela, Roberto; Tzian, Kitze; Monroy Torres, Brian; Romo Pérez, Adriana; Ramírez Apan, María Teresa; Flores Alamo, Marcos; Rodríguez Diéguez, Antonio; Cepeda, Javier; Castillo, IvanEditorial
Springer Nature
Materia
Vanadate–copper complexes Magneto-structural correlations Cytotoxic activity
Date
2024-01-04Referencia bibliográfica
Sánchez-Lara, E., Favela, R., Tzian, K. et al. Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes. J Biol Inorg Chem 29, 139–158 (2024). https://doi.org/10.1007/s00775-023-02035-9
Sponsorship
DGAPA-UNAM for the postdoctoral scholarship; CONAHCyT for the M.Sc. fellowship 1178302; Conahcyt (A1-S-8682); DGAPA-PAPIIT (IN217020, IN216823); Gobierno Vasco/Eusko Jaurlaritza (IT1755-22); Junta de Andalucía (FQM-394)Abstract
The aim to access linked tetravanadate [
V4O12]4− anion with mixed copper(II) complexes, using α-amino acids and
phenanthroline-derived ligands, resulted in the formation of four copper(II) complexes [Cu(dmb)(Gly)(OH2)]2[Cu(dmb)
(Gly)]2[V4O12]·9H2O (1) [Cu(dmb)(Lys)]2[V4O12]·8H2O (2), [Cu(dmp)2][V4O12]·C2H5OH·11H2O (3), and [Cu(dmp)(Gly)
Cl]·2H2O (4), where dmb = 4,4′-dimethioxy-2,2′-bipyridine; Gly = glycine; Lys = lysine; and dmp = 2,9-dimethyl-1,10-phenanthroline.
The [
V4O12]4− anion is functionalized with mixed copper(II) units in 1 and 2; while in 3, it acts as a counterion
of two [Cu(dmp)]2+ units. Compound 4 crystallized as a unit that did not incorporate the vanadium cluster. All compounds
present magnetic couplings arising from Cu⋯O/Cu⋯Cu bridges. Stability studies of water-soluble 3 and 4 by UV–Vis
spectroscopy in cell culture medium confirmed the robustness of 3, while 4 appears to undergo ligand scrambling over time,
resulting partially in the stable species [Cu(dmp)2]+ that was also identified by electrospray ionization mass spectrometry at
m/z = 479. The in vitro cytotoxicity activity of 3 and 4 was determined in six cancer cell lines; the healthy cell line COS-7 was
also included for comparative purposes. MCF-7 cells were more sensitive to compound 3 with an IC50
value of 12 ± 1.2 nmol.
The tested compounds did not show lipid peroxidation in the TBARS assay, ruling out a mechanism of action via reactive
oxygen species formation. Both compounds inhibited cell migration at 5 μM in wound-healing assays using MCF-7, PC-3,
and SKLU-1 cell lines, opening a new window to study the anti-metastatic effect of mixed vanadium–copper(II) systems.