@misc{10481/91393,
year = {2024},
month = {1},
url = {https://hdl.handle.net/10481/91393},
abstract = {The aim to access linked tetravanadate [
V4O12]4− anion with mixed copper(II) complexes, using α-amino acids and
phenanthroline-derived ligands, resulted in the formation of four copper(II) complexes [Cu(dmb)(Gly)(OH2)]2[Cu(dmb)
(Gly)]2[V4O12]·9H2O (1) [Cu(dmb)(Lys)]2[V4O12]·8H2O (2), [Cu(dmp)2][V4O12]·C2H5OH·11H2O (3), and [Cu(dmp)(Gly)
Cl]·2H2O (4), where dmb = 4,4′-dimethioxy-2,2′-bipyridine; Gly = glycine; Lys = lysine; and dmp = 2,9-dimethyl-1,10-phenanthroline.
The [
V4O12]4− anion is functionalized with mixed copper(II) units in 1 and 2; while in 3, it acts as a counterion
of two [Cu(dmp)]2+ units. Compound 4 crystallized as a unit that did not incorporate the vanadium cluster. All compounds
present magnetic couplings arising from Cu⋯O/Cu⋯Cu bridges. Stability studies of water-soluble 3 and 4 by UV–Vis
spectroscopy in cell culture medium confirmed the robustness of 3, while 4 appears to undergo ligand scrambling over time,
resulting partially in the stable species [Cu(dmp)2]+ that was also identified by electrospray ionization mass spectrometry at
m/z = 479. The in vitro cytotoxicity activity of 3 and 4 was determined in six cancer cell lines; the healthy cell line COS-7 was
also included for comparative purposes. MCF-7 cells were more sensitive to compound 3 with an IC50
value of 12 ± 1.2 nmol.
The tested compounds did not show lipid peroxidation in the TBARS assay, ruling out a mechanism of action via reactive
oxygen species formation. Both compounds inhibited cell migration at 5 μM in wound-healing assays using MCF-7, PC-3,
and SKLU-1 cell lines, opening a new window to study the anti-metastatic effect of mixed vanadium–copper(II) systems.},
organization = {DGAPA-UNAM
for the postdoctoral scholarship},
organization = {CONAHCyT for
the M.Sc. fellowship 1178302},
organization = {Conahcyt (A1-S-8682)},
organization = {DGAPA-PAPIIT (IN217020, IN216823)},
organization = {Gobierno Vasco/Eusko Jaurlaritza (IT1755-22)},
organization = {Junta de Andalucía (FQM-394)},
publisher = {Springer Nature},
keywords = {Vanadate–copper complexes},
keywords = {Magneto-structural correlations},
keywords = {Cytotoxic activity},
title = {Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes},
doi = {10.1007/s00775-023-02035-9},
author = {Sánchez Lara, Eduardo and Favela, Roberto and Tzian, Kitze and Monroy Torres, Brian and Romo Pérez, Adriana and Ramírez Apan, María Teresa and Flores Alamo, Marcos and Rodríguez Diéguez, Antonio and Cepeda, Javier and Castillo, Ivan},
}