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Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes
dc.contributor.author | Sánchez Lara, Eduardo | |
dc.contributor.author | Favela, Roberto | |
dc.contributor.author | Tzian, Kitze | |
dc.contributor.author | Monroy Torres, Brian | |
dc.contributor.author | Romo Pérez, Adriana | |
dc.contributor.author | Ramírez Apan, María Teresa | |
dc.contributor.author | Flores Alamo, Marcos | |
dc.contributor.author | Rodríguez Diéguez, Antonio | |
dc.contributor.author | Cepeda, Javier | |
dc.contributor.author | Castillo, Ivan | |
dc.date.accessioned | 2024-05-06T07:40:31Z | |
dc.date.available | 2024-05-06T07:40:31Z | |
dc.date.issued | 2024-01-04 | |
dc.identifier.citation | Sánchez-Lara, E., Favela, R., Tzian, K. et al. Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes. J Biol Inorg Chem 29, 139–158 (2024). https://doi.org/10.1007/s00775-023-02035-9 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/91393 | |
dc.description.abstract | The aim to access linked tetravanadate [ V4O12]4− anion with mixed copper(II) complexes, using α-amino acids and phenanthroline-derived ligands, resulted in the formation of four copper(II) complexes [Cu(dmb)(Gly)(OH2)]2[Cu(dmb) (Gly)]2[V4O12]·9H2O (1) [Cu(dmb)(Lys)]2[V4O12]·8H2O (2), [Cu(dmp)2][V4O12]·C2H5OH·11H2O (3), and [Cu(dmp)(Gly) Cl]·2H2O (4), where dmb = 4,4′-dimethioxy-2,2′-bipyridine; Gly = glycine; Lys = lysine; and dmp = 2,9-dimethyl-1,10-phenanthroline. The [ V4O12]4− anion is functionalized with mixed copper(II) units in 1 and 2; while in 3, it acts as a counterion of two [Cu(dmp)]2+ units. Compound 4 crystallized as a unit that did not incorporate the vanadium cluster. All compounds present magnetic couplings arising from Cu⋯O/Cu⋯Cu bridges. Stability studies of water-soluble 3 and 4 by UV–Vis spectroscopy in cell culture medium confirmed the robustness of 3, while 4 appears to undergo ligand scrambling over time, resulting partially in the stable species [Cu(dmp)2]+ that was also identified by electrospray ionization mass spectrometry at m/z = 479. The in vitro cytotoxicity activity of 3 and 4 was determined in six cancer cell lines; the healthy cell line COS-7 was also included for comparative purposes. MCF-7 cells were more sensitive to compound 3 with an IC50 value of 12 ± 1.2 nmol. The tested compounds did not show lipid peroxidation in the TBARS assay, ruling out a mechanism of action via reactive oxygen species formation. Both compounds inhibited cell migration at 5 μM in wound-healing assays using MCF-7, PC-3, and SKLU-1 cell lines, opening a new window to study the anti-metastatic effect of mixed vanadium–copper(II) systems. | es_ES |
dc.description.sponsorship | DGAPA-UNAM for the postdoctoral scholarship | es_ES |
dc.description.sponsorship | CONAHCyT for the M.Sc. fellowship 1178302 | es_ES |
dc.description.sponsorship | Conahcyt (A1-S-8682) | es_ES |
dc.description.sponsorship | DGAPA-PAPIIT (IN217020, IN216823) | es_ES |
dc.description.sponsorship | Gobierno Vasco/Eusko Jaurlaritza (IT1755-22) | es_ES |
dc.description.sponsorship | Junta de Andalucía (FQM-394) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Vanadate–copper complexes | es_ES |
dc.subject | Magneto-structural correlations | es_ES |
dc.subject | Cytotoxic activity | es_ES |
dc.title | Effects of the tetravanadate [V4O12]4− anion on the structural, magnetic, and biological properties of copper/phenanthroline complexes | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1007/s00775-023-02035-9 | |
dc.type.hasVersion | VoR | es_ES |