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dc.contributor.authorMartínez Férez, Antonio 
dc.contributor.authorGuillamón, Enrique
dc.contributor.authorOchando Pulido, Javier Miguel 
dc.contributor.authorDomínguez Martín, Borja
dc.contributor.authorMut Salud, Nuria
dc.contributor.authorMorales González, José Antonio
dc.contributor.authorBaños Arjona, Alberto
dc.date.accessioned2024-02-05T11:11:24Z
dc.date.available2024-02-05T11:11:24Z
dc.date.issued2024-02-15
dc.identifier.citationLWT - Food Science and Technology 194 (2024) 115809es_ES
dc.identifier.urihttps://hdl.handle.net/10481/88248
dc.description.abstractOnion oil (OO) containing propyl-propane thiosulfinate (PTS) and propyl-propane thiosulfonate (PTSO) is known for various therapeutic properties. However, its industrial use in hydrophilic matrices is challenging due to the lack of physicochemical stability. Applying Box-Behnken design (BBD), we developed an optimal OO microemulsion (OOME) with a minimum droplet size and maximum chemical stability. The OOME comprised 2 % w/w oily phase (high oleic acid sunflower oil), 120 mg/L of OO containing PTS+PTSO, 1.47 % w/w emulsifier (Diacetyl tartaric acid ester of mono-diglycerides, DATEM), 0.25 % stabilizer (xanthan gum) and 573 mM phosphate buffer. Turbidimetry as well as laser and dynamic light scattering over 30 days was used to characterize physical stability of the OOME, assessing chemical stability by HPLC. Cytotoxicity and quantification of cytokines (IL-4 and IL-8) were evaluated in colorectal cancer cells (HT-29, T-84 and SW-837) culture supernatants. After 30 days of storage, OOME remained stable, with no flocculation or coalescence phenomena. It achieved a PTS+PTSO amount of 98 mg/L, a droplet size of 329 nm, a particle size dispersal coefficient of 0.89, and Z-potential was −40.17 mV. The OOME improved the antitumor effect of OO in lines HT-29 and SW-837, as well as its influence on the inflammatory response.es_ES
dc.description.sponsorshipGrupo de Investigación TEP025 Tecnología de Procesos Químicos y Bioquímicoses_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOnion Oiles_ES
dc.subjectMicroemulsiones_ES
dc.subjectStabilityes_ES
dc.subjectAntitumores_ES
dc.subjectAnti-inflammatoryes_ES
dc.titleOptimization of an onion oil microemulsion by response surface methodology for enhanced physicochemical stability and biological activityes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES
dc.identifier.doihttps://doi.org/10.1016/j.lwt.2024.115809


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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