SARS-CoV2 infection: the role of cytokines in COVID-19 disease

Costela Ruiz, Víctor Javier; Illescas Montes, Rebeca; Puerta Puerta, José Manuel; Ruiz Rodríguez, Concepción; Melguizo Rodríguez, Lucía Raquel

doi:10.1016/j.cytogfr.2020.06.001

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Identificadores

URI: https://hdl.handle.net/10481/87820

DOI: 10.1016/j.cytogfr.2020.06.001

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Editorial

Elsevier

Materia

COVID-19

SARS-CoV-2

Chemokines

Growth factors

Cytokine storm

Date

2020-06-02

Referencia bibliográfica

Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, Ruiz C, Melguizo-Rodríguez L. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine Growth Factor Rev. 2020 Aug;54:62-75. doi: 10.1016/j.cytogfr.2020.06.001. Epub 2020 Jun 2. PMID: 32513566; PMCID: PMC7265853.

Sponsorship

Este estudio ha contado con el apoyo del grupo de investigación BIO277 (Junta de Andalucía) y del Departamento de Enfermería de la Universidad de Granada.

Abstract

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

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