SARS-CoV2 infection: the role of cytokines in COVID-19 disease Costela Ruiz, Víctor Javier Illescas Montes, Rebeca Puerta Puerta, José Manuel Ruiz Rodríguez, Concepción Melguizo Rodríguez, Lucía Raquel COVID-19 SARS-CoV-2 Chemokines Growth factors Cytokine storm Elsevier concede permiso para que toda su investigación relacionada con COVID-19 que esté disponible en el centro de recursos COVID-19 -incluido el contenido de esta investigación- esté inmediatamente disponible en PubMed Central y otros repositorios financiados con fondos públicos, como la base de datos COVID de la OMS, con derechos para su reutilización y análisis de investigación sin restricciones en cualquier forma o por cualquier medio con reconocimiento de la fuente original. Estos permisos son concedidos gratuitamente por Elsevier mientras permanezca activo el centro de recursos COVID-19. COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19. 2024-01-31T12:17:26Z 2024-01-31T12:17:26Z 2020-06-02 journal article Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, Ruiz C, Melguizo-Rodríguez L. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine Growth Factor Rev. 2020 Aug;54:62-75. doi: 10.1016/j.cytogfr.2020.06.001. Epub 2020 Jun 2. PMID: 32513566; PMCID: PMC7265853. https://hdl.handle.net/10481/87820 10.1016/j.cytogfr.2020.06.001 eng embargoed access Elsevier