@misc{10481/87820,
year = {2020},
month = {6},
url = {https://hdl.handle.net/10481/87820},
abstract = {COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.},
organization = {Este estudio ha contado con el apoyo del grupo de investigación BIO277 (Junta de Andalucía) y del Departamento de Enfermería de la Universidad de Granada.},
publisher = {Elsevier},
keywords = {COVID-19},
keywords = {SARS-CoV-2},
keywords = {Chemokines},
keywords = {Growth factors},
keywords = {Cytokine storm},
title = {SARS-CoV2 infection: the role of cytokines in COVID-19 disease},
doi = {10.1016/j.cytogfr.2020.06.001},
author = {Costela Ruiz, Víctor Javier and Illescas Montes, Rebeca and Puerta Puerta, José Manuel and Ruiz Rodríguez, Concepción and Melguizo Rodríguez, Lucía Raquel},
}