Infant gut microbiota contributes to cognitive performance in mice
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Cerdó, Tomás; Ruiz Rodríguez, Alicia; Acuña Morales, Inmaculada; Torres Espínola, Francisco José; Menchén Márquez, Sergio; Gámiz Ruiz, Fernando; Gallo Torre, Milagros; Jehmlich, Nico; Haange, Sven-Bastiaan; Von Bergen, Martin; Campoy Folgoso, Cristina; Suárez García, Antonio FranciscoMateria
Cognition Germ-free mice Gut Histidine metabolome Infant Microbiota Metaproteomics
Date
2023Referencia bibliográfica
Published version: Cerdó, Tomás et al. Infant gut microbiota contributes to cognitive performance in mice. Cell Host Microbe. 2023. Dec 13;31(12):1974-1988.e4. [doi: 10.1016/j.chom.2023.11.004]
Sponsorship
Spanish Health and Science Ministries (PREOBE project P06-CTS-02341, BFU2012-40254-C03-01, PID2020-114269GB-I00); Junta de Andalucía; UFZ-Germany; Spanish Ministry of Economy and Competitiveness BES-2013-065133; Carlos III Institute (CD21/00187); María Zambrano Next Generation EU-Talent Reincorporation; UGRAbstract
Gut microbiota has been related to infant neurodevelopment. Here, an association
between infant composite cognition with gut microbiota composition was established as
soon as 6 months. Higher diversity and evenness characterized microbial communities of
infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median
values. Metaproteomic and metabolomic analyses established an association between
microbial histidine ammonia lyase activity and infant histidine metabolome with cognition.
Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice
showed that memory, assessed by novel object recognition test, was a transmissible trait.
Furthermore, Inf-aboveCC mice were enriched in species previously linked to cognition belonging to Bacteroides, Phaeicola and Bifidobacterium. Finally, Inf-aboveCC mice
showed differential faecal histidine, hippocampal urocanate and histidine-urocanate-glutamate ratios compared to Inf-aboveCC mice. Overall, these findings reveal a causative
role of gut microbiota on infant cognition pointing at modulation of histidine metabolite
levels as a potential underlying mechanism.