@misc{10481/86758,
year = {2023},
url = {https://hdl.handle.net/10481/86758},
abstract = {Gut microbiota has been related to infant neurodevelopment. Here, an association
between infant composite cognition with gut microbiota composition was established as
soon as 6 months. Higher diversity and evenness characterized microbial communities of
infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median
values. Metaproteomic and metabolomic analyses established an association between
microbial histidine ammonia lyase activity and infant histidine metabolome with cognition.
Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice
showed that memory, assessed by novel object recognition test, was a transmissible trait.
Furthermore, Inf-aboveCC mice were enriched in species previously linked to cognition belonging to Bacteroides, Phaeicola and Bifidobacterium. Finally, Inf-aboveCC mice
showed differential faecal histidine, hippocampal urocanate and histidine-urocanate-glutamate ratios compared to Inf-aboveCC mice. Overall, these findings reveal a causative
role of gut microbiota on infant cognition pointing at modulation of histidine metabolite
levels as a potential underlying mechanism.},
organization = {Spanish Health and Science Ministries (PREOBE project P06-CTS-02341, BFU2012-40254-C03-01, PID2020-114269GB-I00)},
organization = {Junta de Andalucía},
organization = {UFZ-Germany},
organization = {Spanish Ministry of Economy and Competitiveness  BES-2013-065133},
organization = {Carlos III Institute  (CD21/00187)},
organization = {María Zambrano Next Generation EU-Talent Reincorporation},
organization = {UGR},
keywords = {Cognition},
keywords = {Germ-free mice},
keywords = {Gut},
keywords = {Histidine metabolome},
keywords = {Infant},
keywords = {Microbiota},
keywords = {Metaproteomics},
title = {Infant gut microbiota contributes to cognitive performance in mice},
doi = {10.1016/j.chom.2023.11.004},
author = {Cerdó, Tomás and Ruiz Rodríguez, Alicia and Acuña Morales, Inmaculada and Torres Espínola, Francisco José and Menchén Márquez, Sergio and Gámiz Ruiz, Fernando and Gallo Torre, Milagros and Jehmlich, Nico and Haange, Sven-Bastiaan and Von Bergen, Martin and Campoy Folgoso, Cristina and Suárez García, Antonio Francisco},
}